Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA Protein(C-Fc)
Catalog No.
PKSH032753-10µg
Background
MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1.
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Stability and Storage
Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
Synonym
MHC Class I Polypeptide-Related Sequence A; MIC-A; MICA; PERB11.1
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Endotoxin
＜1.0 EU per µg as determined by LAL test.
Purity
＞95% as determined by reducing SDS-PAGE.
Source
Recombinants or rec. proteins
Expressed Host
Human cells
